The Sisterville to St Marys trail is a 50.10-kilometer hiking route near New Matamoras, Ohio, featuring 331 scenic viewpoints along the historic Ohio River corridor. Following portions of the Lewis & Clark National Historic Trail, this riverside path offers hikers relatively flat terrain at 186 meters elevation with stunning river vistas and rich American history. The trailhead begins at 865 Leith Run Rd, providing access to one of Ohio's most scenic long-distance hiking experiences.